Insulin Potentiation Therapy [A Gentle Approach To Chemotherapy]

Insulin potentiation therapy (IPT) is an intravenous alternative cancer therapy that uses insulin to enhance the efficacy of low-dose chemotherapy. IPT is much gentler than conventional chemotherapy, and doesn’t come with the horrific side effects patients typically have to endure.

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The History Of Insulin Potentiation Therapy

Dr. Steven Ayre is the physician we can thank for bringing IPT to the United States in the 1990s. A family of doctors from Mexico, however, were the ones that invented what is now referred to as Insulin potentiation therapy. Dr Ayre worked alongside these doctors, and the result is the therapy that is used today.

Interestingly, IPT is used as a diagnostic tool in conventional medicine. Before a PET scan is performed, the patient is injected with radioactive glucose. Cancer can be detected by viewing cells that rapidly uptake glucose. IPT is backed by sound science and empirical evidence, and is useful for many types of cancer.

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What Is Insulin Potentiation Therapy?

The efficacy of IPT lies in its ability to deliver low-dose chemotherapy to cancer cells through the use of insulin. Insulin, a hormone secreted by the pancreas, acts as a potentiate, increasing the effectiveness of chemotherapy.

Insulin does this by activating receptors on the cell membranes of cancer cells. Chemotherapy agents can then easily enter the cell where they can target cancerous cells, and prevent their spread. Every cell in the body has insulin receptors that enable glucose to enter.

Together with oxygen, this is how ATP, or energy, is made. The mechanism behind why IPT works, is the fact that cancer cells have an abundance of insulin receptors, even up to ten times more than do normal cells. When insulin is delivered into the bloodstream, these cell receptors open, ushering in the chemotherapy drugs.

If you’d like to learn more about IPT, “The Kinder, Gentler Cancer Treatment” is a great resource.

Fermentation And Cancer

Cancer cells differ from healthy cells due to their inability to utilize oxygen to produce energy. Because of this inability, cancer cells make energy via glycolysis or fermentation, resulting in their need for copious amounts of glucose to survive.

This is why people with cancer should eliminate sugar from their diets. Not only does glucose feed cancer, it also deprives healthy cells of nutrition, because cancer cells consume the incoming fuel first, leaving little for normal cells. This survival mechanism, along with the abundance in insulin receptors, allows cancer cells to consume more glucose.

More insulin receptors equate to more glucose entering the cell. IPT can effectively target cancer cells due to their increased permeability, and affinity to quickly bind insulin. Healthy cells don’t bind insulin as quickly because they don’t have as many insulin receptors. This is one of the reasons IPT doesn’t harm normal cells.

IPT capitalizes on cancer’s extreme need for sugar to deliver chemo into the cells. Insulin, which is used off-label as an adjunct to increase cell membrane permeability, is a causal factor behind the success of IPT. Although, both insulin and chemotherapy are FDA approved drugs, IPT is still considered an alternative cancer therapy.

“Balance Your Health: Combining Conventional and Natural Medicine” by Richard Sollazzo is another informative resource.

Insulin Potentiation Therapy - Heat Lamps


Low Dose Chemotherapy

Insulin exponentially increases the absorption rates of chemotherapy. That is why the term “potentiate” is used to describe this type of therapy. “Potentiate” means to “intensify”or “multiply.”  Because of this increased absorption rate, much lower doses of chemo can be used.

With IPT, only 5-10% of the conventional standard chemotherapy dose is delivered. The amount of insulin that is given is equivalent to what the body would secrete following a normal meal. These low doses spare the patient immense suffering, while still delivering the cancer-killing benefits.

Healthy cells are protected from low-dose chemotherapy because their cell membranes are less permeable as a result of having fewer insulin receptors. The more receptors a cell has, the more permeable it becomes. This is why IPT is so effective in attacking cancer.

Insulin also activates an enzyme called delta-9 desaturase. When activated, this enzyme increases cell-membrane permeability by desaturating the fatty acids within the membranes themselves, allowing the chemo drugs to easily enter.

The Therapeutic Window

Before receiving IPT, a patient refrains from eating for up to 12 hours prior to treatment. A small dose of insulin is then administered, saturating the numerous insulin receptors on the membranes of cancer cells. These receptors become saturated within 20-40 minutes. Small doses of chemo are then administered and absorbed by cancer cells.

During this “therapeutic window,” noncancerous cells remain untouched because their receptors have not been saturated. This entire process is halted once the patient resumes eating.

In traditional chemotherapy, large amounts of cytotoxic drugs are used, in order for enough of the drug to be absorbed, to make the treatment effective. Unfortunately, healthy cells are also harmed in this process, and the immune system takes a huge hit.

Because IPT uses lower doses of chemo, treatment can be administered more frequently. This reduces the chances of cancer cells becoming drug-resistant, while furthering the process of apoptosis, or programmed cell death.

Benefits Of Insulin Potentiation Therapy

We’re all familiar with the miserable side effects associated with traditional chemotherapy. Nausea and vomiting, extreme fatigue and hair loss are just a few of the symptoms that are part and parcel of chemotherapy treatment. Quality of life greatly diminishes, and the toxicity of chemo is often a factor in the demise of the patient. In many cases, chemotherapy kills.

Insulin potentiation therapy uses a much gentler approach. The patient receives all the advantages of chemotherapy without experiencing the extreme discomfort so common with high-dose chemo. Another significant benefit is that the immune system is not obliterated.

It can then do its job of defending the body, not only against cancer, but against infectious organisms, toxic chemicals, radiation, and EMFs.

Benefits include:

  • Lower doses of chemo can be used
  • Treatment can be administered more frequently
  • DNA damage does not occur
  • The immune system is spared
  • No side effects are noted
  • Drug-resistance is not an issue
  • Cachexia, or muscle wasting, is nonexistent
  • Apoptosis is stimulated
  • Increased cell-membrane permeability
  • Can be used for conditions other than cancer
  • Increases the potency and absorption of chemotherapy

One potential side effect of IPT is hypoglycemia or low blood sugar. This isn’t an issue, however, if the patient is carefully monitored.

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Key Points

Insulin potentiation therapy is an alternative cancer therapy that uses insulin and low-dose chemotherapy. Insulin, a pancreatic hormone, opens receptors on cancer cells, allowing chemotherapy to enter where it can accomplish its job of killing cancer and preventing its spread.

The mechanism behind how IPT works is based on human biochemistry, and the distinguishing characteristics of cancer cells. It was first brought to the USA in the 1990s, and is now being used successfully in alternative cancer clinics in the United States, Mexico, and Europe. One such clinic is An Oasis of Healing in Arizona.

Have you or a loved one been treated with IPT? Let me know in the comments:)


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[1] CAM Cancer: Insulin potentiation therapy

[2] Arizona Center For Advanced Medicine: Frequently Asked Questions About IPT-LD

[3] Research Gate: Insulin Potentiation Therapy in the Treatment of Malignant Neoplastic Diseases: A Three Year Study Christo Damyanov, Gherasimova DM, Avramov LA and Masley IK

[4] The Nevada Center of Alternative & Anti-Aging Medicine: INSULIN POTENTIATION CANCER THERAPY

[5] ScienceDirect: Insulin potentiation therapy: A new concept in the management of chronic degenerative disease


Disclaimer: This article is strictly for informational purposes only and is not intended to be medical advice.

10 thoughts on “Insulin Potentiation Therapy [A Gentle Approach To Chemotherapy]”

  1. Although I do not know anyone who has been treated using IPT, I cannot understand why not. Your article clearly spells out its benefits and absence of side effects.

    How extensive is the research surrounding the side effects? Also, if the FDA considers it an “alternative” treatment that means most insurance won’t cover it. How is someone supposed to be able to afford it without insurance?

    Keep spreading the word, this seems like the next advancement in curing cancer.


    • IPT is an amazing therapy, but unfortunately in most cases, is unlikely to be covered by insurance. Hypoglycemia is a potential side effect, but is a non issue if the patient is monitored closely. 

      I appreciate you reading and commenting.

  2. Thank you very much for this great and amazing post. I think you must have put a lot if energy into writing this and I really appreciate that. I think we all owe Dr. Ayre a lot for coming up with the Insulin Potentiation Therapy. It’s a big boost for people battling cancer. I hope this can help many people. 

  3. Oh wow, I never heard about this! I admit I’m not familiar with alternative ways to treat cancer. I only know about chemotherapy and I know the serious side effects of that. Thank you for listing the history and benefits of IPT. I learned a ton of great info from your article!

    • Hi Ariana,

      Not many people are familiar with IPT. It’s an alternative therapy that doesn’t have any side effects.  

  4. Thanks for the insight. I had a family member who had cancer and after being treated with the conventional chemotherapy wasnt getting better until he was flown out of the country and treated with IPT. It is truly an  amazing treatment and he has started getting better. It was nice learning more about IPT in your article.

  5. We need more of these articles now that cancer is becoming more rampant. This is the first time I have read about insulin Potentiation Therapy. I know it will help my future research on cancer-relation issues. 

     I’m happy I somehow find my way to your site. Thanks for this write up.


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