Low Dose Naltrexone For Cancer?

Naltrexone is an FDA-approved drug to treat heroin and opiate addiction. Used in low doses, and off-label, it is now being used to treat a variety of conditions, ranging from multiple sclerosis, AIDs, Alzheimer’s, and Crohn’s disease. What about low dose naltrexone for cancer?

Low Dose Naltrexone For Cancer?

What Is Naltrexone?

Naltrexone is a powerful, non-narcotic opioid antagonist, meaning it blocks the effects of narcotic drug use, and is also used in the treatment of alcohol addiction. Its effectiveness lies in its ability to block the “high” associated with substance abuse. In this way, it is used to prevent relapses in addicts who have become dependent.

It’s much easier to treat addiction when the desire for the chosen drug is reduced, cravings are decreased, and the detoxification process shortened. Unfortunately, naltrexone also blocks endogenously made endorphins, leading to symptoms such as depression, insomnia, paranoia, joint pain, and GI problems.

Interestingly, when used in low doses, LDN alleviates these very symptoms. Doses of 25-50 mg of naltrexone are given to control withdrawal symptoms. Compare this dosage to the low doses – 1.5 to 6 mg of naltrexone that are used – to treat autoimmunity, cancer, and a wide array of chronic diseases.


Low dose naltrexone (LDN) doesn’t heal directly, rather it induces the body to heal itself by increasing the production of endorphins in the brain. In fact, treatment using LDN, is a form of Hormesis. This phenomenon happens when low doses of a substance exert a beneficial effect, whereas higher doses of the same substance would be toxic.

Exercise is a good example of hormesis, with the exercise-induced stress on the body, resulting in the body becoming stronger and more resilient. 

What Are Endorphins?

Endorphins play a significant role in addiction. Most of us associate endorphins with the pleasant feelings we feel after exercise. Endorphins are the peptide chemicals that produce the infamous “runner’s high” or give athletes that much needed “second wind.” High levels produce blissful feelings, while low levels are linked to addiction, anxiety, and chronic pain.

Endorphins are morphine-like chemicals produced endogenously in the nervous system. This means the body naturally produces them. These chemicals work with the opiate receptors found in the brain and spinal cord to reduce pain and promote feelings of well-being. They are extremely powerful, and can be up to 500 times more efficacious than man-made painkillers.

And because endorphins are natural chemicals made within the body, they are non-addictive. Endorphins are hormones that mimic the effects of heroin.  Over 20 different endorphins have been identified in the human body that are responsible for enhanced immunity, pain relief, and stress reduction.

Endorphins are believed to retard aging. Perhaps, this is why people who exercise look younger. Meditation, exercise, deep breathing, and laughter are all therapeutic practices due to the endorphin rush they initiate.

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What Is Naltrexone Used For?

In low doses, naltrexone is used to treat autoimmune diseases, eating and behavorial disorders, skin conditions, irritable bowel diseases, infectious diseases such as HIV and Lyme disease, and many types of cancer. It has been theorized that people with these conditions have low levels of endorphins, which negatively affects immune function.

LDN is also used for fatigue syndromes like fibromyalgia and chronic fatigue. Even those suffering from anxiety and depression can become less symptomatic by taking LDN. Here are more conditions that respond well to LDN:

How Does LDN Work?

From 2:00 to 4:00 a.m. in the morning, the brain receives signals from the pituitary and adrenal glands to make endorphins. When LDN is given before bed, opioid receptors are blocked. The body’s response to this blockage is an upregulation of essential immune system components, and up to a 300% increase in endorphin production.

By giving LDN several hours before this process occurs, endorphin production skyrockets. These endorphins are responsible for the success rate of LDN. Another benefit of these elevated endorphin levels is induced apoptosis of cancer cells, an important mechanism that aids in preventing cancer.

Since endorphin deficiency is linked to substance abuse, poor immune function, mental health disorders, pain syndromes, infections, allergies, obesity, heart disease, and autoimmunity, it would stand to reason that correcting a deficiency state, would eliminate these symptoms.


LDN is used homeopathically. This means it is not used for its direct effect on the body, but rather the body’s reaction to it, namely improving immune function, and promoting endorphin release, notably metenkephalin and beta-endorphin, two highly abundant endorphins.

If you want to read more about LDN, here’s an informative overview of what it is and how it works: The Promise Of Low Dose Naltrexone Therapy. Potential Benefits In Cancer, Autoimmune, Neurological and Infectious Disorders.

LDN And Cancer

Dr. Bihari is the doctor responsible, for the groundbreaking clinical trials he conducted of AIDs patients, who were given LDN. These patients were extremely ill, and most of them failed to respond to various treatments. Bihari observed that when these patients took LDN, their crippled immune systems were protected.

LDN is showing great promise in the area of cancer due to its amazing effects on the immune system, culminating in reductions in tumor growth, and inhibited angiogenesis. This is significant because angiogenesis is the process of new blood vessel formation that fuels cancer growth. In this way, LDN can halt disease progression.

LDN targets opioid growth factor and opioid growth factor receptor pathways, inhibiting cell proliferation, while increasing the number of circulating natural killer cells, lymphocytes, and cytotoxic T cells, important immune system molecules. When used in conjunction with conventional cancer drugs, LDN has been show to increase their efficacy.

LDN relieves pain and improves mood, both of which promote healing. Elevated levels of endorphins enhance immunity, which in turn mitigates pain by combating infections, inflammation, allergies, autoimmune diseases, and cancer.

The LDN Book: How A Little-Known Generic Drug –  Low Dose Naltrexone – Could Revolutionize Treatment for Autoimmune Diseases, Cancer, Autism, Depression, and More. 

Types Of Cancers

Dr. Bihari reported that certain cancers respond favorably to treatment with LDN. They are:

Neuroblastoma and glioblastoma

Lung (non-small cell) and breast cancers

Colon and rectal cancers 

Uterine, ovarian and endometrial cancers

Lymphocyte leukemia (chronic)

Lymphoma – Hodgkins’ and non-Hodgkin’s

Prostate cancer (untreated)

Throat and pancreatic cancers

Malignant melanoma

Not surprisingly, patients who showed the most progress had never been treated with chemotherapy.

Low Dose Naltrexone Therapy

Typical doses of LDN fall in the 3.0 – 4.5 mg range. Dosage depends on several factors, including how much the person weighs, their individual sensitivity to the medication, and the absorption and excretion rate.  Another significant factor is liver and kidney health. Some people may do fabulously on 1/4 the average dose, while others may need three times that amount.

Starting doses begin at 0.5 to 1.5 mg and are increased slowly over a couple of months in increments of 0.5 mg. The optimal dose of LDN is 4.5 mg, although this can vary significantly based on the factors above. Keep in mind, LDN should not be taken the week preceding and following treatment with chemotherapy.

It is recommended that LDN be taken at night on an empty stomach. When I was on LDN, I would eat dinner at my usual time, and wait two hours before taking it. To optimize absorption, no food or water should be consumed one hour after taking LDN.

Taking it at night is key to maximum endorphin release because LDN can then work with the body’s diurnal rhythms as 90% of endorphins are produced in the middle of the night. By dosing the medication in the evening, endorphin production increases threefold.


Low Dose Naltrexone Side Effects

Unlike naltrexone, people experience few negative symptoms when taking LDN. When side effects are noted, they are typically mild and temporary. Sleep disturbances, along with vivid dreams, fatigue, and spasms are potential reactions, but usually resolve within a week.

Headaches, vomiting and diarrhea have also been noted, but are often linked to previous analgesic use, which can cause an increased sensitivity to pain. Because LDN blocks the analgesic effects of opiates, it may initially increase pain, and cause a withdrawal reaction. To prevent this, opiate-type medications should not be used two weeks prior to treatment with LDN.

Titration is crucial to prevent negative reactions. Most people experiencing side effects began with doses of 3.0 mg or higher. Reactions should be nonexistent, or at least minimal, when treatment is started using very small doses of 0.5 mg, gradually titrating upwards until the ideal dose is reached.

Key Points

Low dose naltrexone is highly effective against a wide range of conditions due to its ability to activate the immune system through endorphin release. LDN is unique in that it does not treat disease the way other drugs do, but promotes healing through indirect mechanisms.

LDN is efficacious in the treatment of cancer because of its effects on angiogenesis, apoptosis, and cell proliferation. It is inexpensive, widely available, and safe. If you or a loved one are fighting cancer, please dive deeper into the benefits of LDN as it could be an integral part of your healing protocol.

Have you heard of LDN? Please share your experience with this wonderful medication that is used off-label to treat cancer.

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